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Article

Evaluation of Parkinson disease risk variants as expression-QTLs.

PloS one - 1 Jan 2012

Latourelle Jeanne C, Dumitriu Alexandra, Hadzi Tiffany C, Beach Thomas G, Myers Richard H

Abstract excerpt

The recent Parkinson Disease GWAS Consortium meta-analysis and replication study reports association at several previously confirmed risk loci SNCA, MAPT, GAK/DGKQ, and HLA and identified a novel risk locus at RIT2. To further explore functional consequences of these associations, we investigated modification of gene expression in prefrontal cortex brain samples of pathologically confirmed PD cases (N = 26) and...

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Topics

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Share to MAPT gene
Share to SNCA gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotide Array Sequence Analysis

Share to Parkinson Disease

Share to Parkinson's Disease Mechanisms and Treatments

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 23071545
DOI: 10.1371/journal.pone.0046199
PMCID: PMC3465315

Genes

MAPT
RIT2
SNCA
DCAKD
DGKQ
GAK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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