Article
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Annals of neurology - 1 Mar 2012
Pankratz Nathan, Beecham Gary W, DeStefano Anita L, Dawson Ted M, Doheny Kimberly F, Factor Stewart A, Hamza Taye H, Hung Albert Y, Hyman Bradley T, Ivinson Adrian J, Krainc Dmitri, Latourelle Jeanne C, Clark Lorraine N, Marder Karen, Martin Eden R, Mayeux Richard, Ross Owen A, Scherzer Clemens R, Simon David K, Tanner Caroline, Vance Jeffery M, Wszolek Zbigniew K, Zabetian Cyrus P, Myers Richard H, Payami Haydeh, Scott William K, Foroud Tatiana
Abstract excerpt
OBJECTIVE: Genome-wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes associated with PD susceptibility. METHODS: A 2-stage design was used. First, individual level genotypic data from 5 recent PD GWAS (Discovery Sample: 4,238 PD cases and 4,239 controls) were combined. Following imputation, a logistic regression model was employed...
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