Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics.

PloS one - 1 Jan 2012

Dinu Irina, Mahasirimongkol Surakameth, Liu Qi, Yanai Hideki, Sharaf Eldin Noha, Kreiter Erin, Wu Xuan, Jabbari Shahab, Tokunaga Katsushi, Yasui Yutaka

Abstract excerpt

In genome-wide association studies (GWAS), the association between each single nucleotide polymorphism (SNP) and a phenotype is assessed statistically. To further explore genetic associations in GWAS, we considered two specific forms of biologically plausible SNP-SNP interactions, 'SNP intersection' and 'SNP union,' and analyzed the Crohn's Disease (CD) GWAS data of the Wellcome Trust Case Control Consortium for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CYLD gene

Share to Genome-Wide Association Study

Share to Logistic Models

Share to Membrane Proteins

Share to Organic Anion Transporters

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 23071489
DOI: 10.1371/journal.pone.0043035
PMCID: PMC3470545

Genes

CYLD
ISX
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics.PMID 23071489Read ↗

A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease.Semantic proximity Read ↗

Discovering genetic variants in Crohn's disease by exploring genomic regions enriched of weak association signals.Semantic proximity Read ↗

In-silico analysis of inflammatory bowel disease (IBD) GWAS loci to novel connections.Semantic proximity Read ↗

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.Semantic proximity Read ↗

Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes.Semantic proximity Read ↗

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.Semantic proximity Read ↗

Moving from GWAS signals to rare functional variation in inflammatory bowel disease through application of GenePy2 as a potential DNA biomarkerSemantic proximity Read ↗

Crohn's Disease Susceptibility Gene Interactions, a NOD to the Newcomer ATG16L1Semantic proximity Read ↗

Association and Pathogenic Mechanisms of Solute Carrier-related Genes in Crohn's DiseaseSemantic proximity Read ↗

Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.Semantic proximity Read ↗

RS-SNP: a random-set method for genome-wide association studies.Semantic proximity Read ↗

New links to the pathogenesis of Crohn disease provided by genome-wide association scans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.