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Article

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.

Human molecular genetics - 1 Apr 2004

van Heel David A, Fisher Sheila A, Kirby Andrew, Daly Mark J, Rioux John D, Lewis Cathryn M

Abstract excerpt

Crohn's disease and ulcerative colitis (the inflammatory bowel diseases) have a strong genetic component. Although over 20 putative susceptibility loci have been identified by individual genome scans, the majority of these loci have not been replicated. Many individual studies are at the lower limit of acceptable power for complex disease linkage analysis. Genome scan meta-analysis (GSMA), by use of sample sizes...

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PMID: 14976156
DOI: 10.1093/hmg/ddh090

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