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Article

A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease.

Inflammatory bowel diseases - 1 Aug 2013

Wang Ming-Hsi, Fiocchi Claudio, Ripke Stephan, Zhu Xiaofeng, Duerr Richard H, Achkar Jean-Paul

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified at least 71 Crohn's disease (CD) genetic risk loci, but the role of gene-gene interactions is unclear. The value of genetic variants in clinical practice is not defined because of limited explained heritability. METHODS: We examined model predictability of combining the 71 CD risk alleles and genetic interactions in an ongoing inflammatory bowel disease...

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Identifiers

PMID: 23598818
DOI: 10.1097/MIB.0b013e31828706a0
PMCID: PMC3720692

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NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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