Article
Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes.
Human molecular genetics - 15 Jul 2015
Ning Kaida, Gettler Kyle, Zhang Wei, Ng Sok Meng, Bowen B Monica, Hyams Jeffrey, Stephens Michael C, Kugathasan Subra, Denson Lee A, Schadt Eric E, Hoffman Gabriel E, Cho Judy H
Abstract excerpt
Genome-wide association studies in Crohn's disease (CD) have identified 140 genome-wide significant loci. However, identification of genes driving association signals remains challenging. Furthermore, genome-wide significant thresholds limit false positives at the expense of decreased sensitivity. In this study, we explored gene features contributing to CD pathogenicity, including gene-based association data from...
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