Article
New partners in regulation of gene expression: the enhancer of Trithorax and Polycomb Corto interacts with methylated ribosomal protein l12 via its chromodomain.
PLoS genetics - 1 Jan 2012
Coléno-Costes Anne, Jang Suk Min, de Vanssay Augustin, Rougeot Julien, Bouceba Tahar, Randsholt Neel B, Gibert Jean-Michel, Le Crom Stéphane, Mouchel-Vielh Emmanuèle, Bloyer Sébastien, Peronnet Frédérique
Abstract excerpt
Chromodomains are found in many regulators of chromatin structure, and most of them recognize methylated lysines on histones. Here, we investigate the role of the Drosophila melanogaster protein Corto's chromodomain. The Enhancer of Trithorax and Polycomb Corto is involved in both silencing and activation of gene expression. Over-expression of the Corto chromodomain (CortoCD) in transgenic flies shows that it is...
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