Article
Drosophila vigilin, DDP1, localises to the cytoplasm and associates to the rough endoplasmic reticulum.
Biochimica et biophysica acta - 1 Jan 2011
Batlle Marta, Marsellach Francesc-Xavier, Huertas Dori, Azorín Fernando
Abstract excerpt
Functional characterisation of vigilin, a highly conserved multi-KH-domain protein that binds RNA and ssDNA, remains elusive and, to some extent, controversial. Studies performed in Saccharomyces cerevisiae and human cells indicate that vigilin localises to the cytoplasm, binds ribosomes, associates to RER and regulates mRNA translation. On the other hand, we and others reported a contribution to...
Topics
- Animals
- Animals, Genetically Modified
- Blotting, Western
- Cells, Cultured
- Cytoplasm
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Endoplasmic Reticulum, Rough