Article
Single amino-acid mutation in a Drosoph ila melanogaster ribosomal protein: An insight in uL11 transcriptional activity.
PloS one - 1 Jan 2022
Grunchec Héloïse, Deraze Jérôme, Dardalhon-Cuménal Delphine, Ribeiro Valérie, Coléno-Costes Anne, Dias Karine, Bloyer Sébastien, Mouchel-Vielh Emmanuèle, Peronnet Frédérique, Thomassin Hélène
Abstract excerpt
The ribosomal protein uL11 is located at the basis of the ribosome P-stalk and plays a paramount role in translational efficiency. In addition, no mutant for uL11 is available suggesting that this gene is haplo-insufficient as many other Ribosomal Protein Genes (RPGs). We have previously shown that overexpression of Drosophila melanogaster uL11 enhances the transcription of many RPGs and Ribosomal Biogenesis...
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