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Article

Mutation mismatch repair gene deletions in diffuse large B-cell lymphoma.

Leukemia & lymphoma - 1 May 2013

Couronné Lucile, Ruminy Philippe, Waultier-Rascalou Agathe, Rainville Vinciane, Cornic Marie, Picquenot Jean-Michel, Figeac Martin, Bastard Christian, Tilly Hervé, Jardin Fabrice

Abstract excerpt

To further unravel the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL), we performed high-resolution comparative genomic hybridization on lymph node biopsies from 70 patients. With this strategy, we identified microdeletions of genes involved in the mutation mismatch repair (MMR) pathway in two samples. The first patient presented with a homozygous deletion of MSH2-MSH6 due to duplication of an...

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Topics

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Share to Chromosomes, Human, Pair 2
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Immunoglobulin Switch Region

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mismatch Repair Endonuclease PMS2

Share to PAX5 Transcription Factor

Share to Proto-Oncogene Proteins c-bcl-6

Source

Identifiers

PMID: 23066952
DOI: 10.3109/10428194.2012.739687

Genes

MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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