Article
Automated screening for genomic imbalances using matrix-based comparative genomic hybridization.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2002
Wessendorf Swen, Fritz Björn, Wrobel Gunnar, Nessling Michelle, Lampel Stefan, Göettel Daniel, Küepper Manfred, Joos Stefan, Hopman Ton, Kokocinski Felix, Döhner Hartmut, Bentz Martin, Schwäenen Carsten, Lichter Peter
Abstract excerpt
Genome-wide screening for chromosomal imbalances using comparative genomic hybridization (CGH) revealed a wealth of data on previously unrecognized tumor-specific genomic alterations. CGH to microarrays of DNA, an approach termed matrix-CGH, allows detection of genomic imbalances at a much higher resolution. We show that matrix CGH is also feasible from small tissue samples requiring universal amplification of...
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