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DNA Mismatch Repair Deficiency in Breast Carcinoma

19 Sept 2012

Abstract excerpt

Recent studies have suggested that breast cancer is part of the tumor spectrum in Lynch syndrome (LS). However, the frequency and significance of DNA mismatch repair (MMR) deficiency in breast carcinoma in general is unclear. Some triple-negative breast carcinomas (TNBCs) have morphologic features similar to those described in LS-associated colorectal carcinomas; therefore, we hypothesized that TNBCs might be...

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PMID: 22992699
DOI: 10.1097/pas.0b013e3182627787

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