Article
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
Nature medicine - 25 Sept 2011
Diouf Barthelemy, Cheng Qing, Krynetskaia Natalia F, Yang Wenjian, Cheok Meyling, Pei Deqing, Fan Yiping, Cheng Cheng, Krynetskiy Evgeny Y, Geng Hui, Chen Siying, Thierfelder William E, Mullighan Charles G, Downing James R, Hsieh Peggy, Pui Ching-Hon, Relling Mary V, Evans William E
Abstract excerpt
DNA mismatch repair enzymes (for example, MSH2) maintain genomic integrity, and their deficiency predisposes to several human cancers and to drug resistance. We found that leukemia cells from a substantial proportion of children (∼11%) with newly diagnosed acute lymphoblastic leukemia have low or undetectable MSH2 protein levels, despite abundant wild-type MSH2 mRNA. Leukemia cells with low levels of MSH2...
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