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Article

Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma.

International journal of hematology - 1 Oct 2006

Hiraga Junji, Kinoshita Tomohiro, Ohno Toshihito, Mori Naoyoshi, Ohashi Haruhiko, Fukami Shouko, Noda Atsuhiko, Ichikawa Atsushi, Naoe Tomoki

Abstract excerpt

The gene for the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related with cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation in several human cancers, including malignant lymphoma. Promoter hypermethylation of the MGMT gene...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

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Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to O(6)-Methylguanine-DNA Methyltransferase

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Source

Identifiers

PMID: 17050200
DOI: 10.1532/IJH97.06087

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17050200-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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