DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma.

doi:10.1080/2162402X.2024.2384667

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Article

DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma.

Oncoimmunology - 1 Jan 2024

Xu-Monette Zijun Y, Luo Cancan, Yu Li, Li Yong, Bhagat Govind, Tzankov Alexandar, Visco Carlo, Fan Xiangshan, Dybkaer Karen, Sakhdari Ali, Wang Nicholas T, Yuan Alyssa F, Chiu April, Tam Wayne, Zu Youli, Hsi Eric D, Perry Anamarija M, Song Wenting, O'Malley Dennis, Au Qingyan, Nunns Harry, Go Heounjeong, Møller Michael B, Parsons Benjamin M, Montes-Moreno Santiago, Ponzoni Maurilio, Ferreri Andrés J M, Sohani Aliyah R, Abramson Jeremy S, Xu Bing, Young Ken H

Abstract excerpt

Deficient (d) DNA mismatch repair (MMR) is a biomarker predictive of better response to PD-1 blockade immunotherapy in solid tumors. dMMR can be caused by mutations in MMR genes or by protein inactivation, which can be detected by sequencing and immunohistochemistry, respectively. To investigate the role of dMMR in diffuse large B-cell lymphoma (DLBCL), MMR gene mutations and expression of MSH6, MSH2, MLH1, and...

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Identifiers

PMID: 39108501
DOI: 10.1080/2162402X.2024.2384667
PMCID: PMC11302547

Genes

MSH6
PMS2
MLH1
MSH2
MYC
PAX5

Provenance

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