Article
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.
Genes & development - 15 Jan 2004
Vella Monica C, Choi Eun-Young, Lin Shin-Yi, Reinert Kristy, Slack Frank J
Abstract excerpt
Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3'UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3'UTR. This interaction...
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