Article
Vav1 haploinsufficiency in a common variable immunodeficiency patient with defective T-cell function.
International journal of immunopathology and pharmacology - 1 Jan 2000
Capitani N, Ariani F, Amedei A, Pezzicoli A, Matucci A, Vultaggio A, Troilo A, Renieri A, Baldari C T, D' Elios M M
Abstract excerpt
Common variable immunodeficiency (CVID) is a primary immune disorder characterized by impaired antibody production, which is in many instances secondary to defective T cell function (T-CVID). We previously identified a subset of T-CVID patients characterized by defective expression of Vav1, a guanine nucleotide exchanger which couples the T-cell antigen receptor to reorganization of the actin cytoskeleton. Here...
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