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Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification

23 Nov 2018

Abstract excerpt

Common variable immune deficiency disorder (CVID) is the most clinically relevant cause of antibody failure. It is a highly heterogeneous disease with different underlying etiologies. CVID has been associated with a quantitative B cell defect, however, little is known about the quality of B cells present. Here, we studied the naïve and antigen selected B-cell receptor (BCR) repertoire in 33 CVID patients using...

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PMID: 30532750
DOI: 10.3389/fimmu.2018.02545

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