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Article

Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2000

Bonhomme D, Hammarström L, Webster D, Chapel H, Hermine O, Le Deist F, Lepage E, Romeo P H, Levy Y

Abstract excerpt

Common variable immunodeficiency (CVID) is an heterogeneous syndrome characterized by decreased levels of serum Ig and recurrent bacterial infection. Here, we were interested to study whether a qualitative defect of the affinity Ab maturation process could be combined to the low level of serum Ig in a cohort of 38 CVID patients. For this, we designed a novel and rapid screening test for the detection of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11035117
DOI: 10.4049/jimmunol.165.8.4725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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