Article
Somatic Hypermutation Defects in Common Variable Immune Deficiency.
Current allergy and asthma reports - 5 Oct 2017
Almejun María Belén, Borge Mercedes
Abstract excerpt
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recurrent infections. In the last 20 years, several groups have reported that B cells from CVID patients have an impaired somatic hypermutation (SHM). The reported frequency of this defect among CVID patient cohorts is highly variable and so is the methodology used to evaluate this process....
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