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Article

Thymocyte selection in Vav and IRF-1 gene-deficient mice.

Immunological reviews - 1 Oct 1998

Penninger J M, Mak T W

Abstract excerpt

T cells undergo a defined program of phenotypic and genetic changes during differentiation within the thymus. These changes define commitment of T-cell receptor (TCR) gamma delta and TCR alpha beta cells and lineage differentiation into CD4+ T helper and CD8+ cytotoxic T cells. T-cell differentiation and selection in the thymus constitute a tightly co-ordinated multistep journey through a network that can be...

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PMID: 9850859
DOI: 10.1111/j.1600-065x.1998.tb01237.x

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