Article
Thymocyte selection in Vav and IRF-1 gene-deficient mice.
Immunological reviews - 1 Oct 1998
Penninger J M, Mak T W
Abstract excerpt
T cells undergo a defined program of phenotypic and genetic changes during differentiation within the thymus. These changes define commitment of T-cell receptor (TCR) gamma delta and TCR alpha beta cells and lineage differentiation into CD4+ T helper and CD8+ cytotoxic T cells. T-cell differentia...
Topics
- Alleles
- Animals
- Cell Cycle Proteins
- Cell Differentiation
- DNA-Binding Proteins
- Humans
- Interferon Regulatory Factor-1
- Mice
- Mice, Knockout
- Phosphoproteins
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-vav
- Receptors, Antigen, T-Cell, alpha-beta
- Signal Transduction
- T-Lymphocytes
- Thymus Gland
- Viruses