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Article

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” Phenotype

8 Oct 2012

Abstract excerpt

BACKGROUND: Plasmodium falciparum-infected erythrocytes (IEs) adhere to host cell receptors, allowing parasites to sequester into deep vascular beds of various organs. This defining phenomenon of malaria pathogenesis is key to the severe clinical complications associated with cerebral and placental malaria. The principal ligand associated with the binding to chondroitin sulfate A (CSA) that allows placental...

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PMID: 23045626
DOI: 10.1093/infdis/jis629

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Research trail→

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First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” PhenotypePMID 23045626Read ↗

Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.Semantic proximity Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

Evidence for the Involvement of VAR2CSA in Pregnancy-associated MalariaSemantic proximity Read ↗

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental MalariaSemantic proximity Read ↗

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.Semantic proximity Read ↗

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.Semantic proximity Read ↗

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected ErythrocytesSemantic proximity Read ↗

Molecular Principles of Intrauterine Growth Restriction in Plasmodium Falciparum InfectionSemantic proximity Read ↗

An Upstream Open Reading Frame Controls Translation of var2csa, a Gene Implicated in Placental MalariaSemantic proximity Read ↗

Selective upregulation of a single distinctly structured <i>var</i> gene in chondroitin sulphate A‐adhering <i>Plasmodium falciparum</i> involved in pregnancy‐associated malariaSemantic proximity Read ↗

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.Semantic proximity Read ↗

VAR2CSA and protective immunity against pregnancy-associated<i>Plasmodium falciparum</i>malariaSemantic proximity Read ↗

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