Article
High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.
The Journal of infectious diseases - 15 Jul 2005
Tuikue Ndam Nicaise G, Salanti Ali, Bertin Gwladys, Dahlbäck Madeleine, Fievet Nadine, Turner Louise, Gaye Alioune, Theander Thor, Deloron Philippe
Abstract excerpt
Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique variant surface antigens that are involved in the placental sequestration that precipitates pregnancy-associated malaria (PAM). Two var gene subfamilies, var1csa and var2csa, have been associated with CSA binding. We show here that placental P. falciparum isolates highly transcribed var2csa but not var1csa. var2csa was not...
Topics
- Animals
- Antigens, Protozoan
- Base Sequence
- Chondroitin Sulfates
- DNA Primers
- Female
- Genetic Variation
- Humans
- Malaria, Falciparum
- Placenta
- Plasmodium falciparum