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Article

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.

The Journal of infectious diseases - 1 Jun 2011

Sander Adam F, Salanti Ali, Lavstsen Thomas, Nielsen Morten A, Theander Thor G, Leke Rose G F, Lo Yeung Y, Bobbili Naveen, Arnot David E, Taylor Diane W

Abstract excerpt

Placental malaria infections are caused by Plasmodium falciparum-infected red blood cells sequestering in the placenta by binding to chondroitin sulfate A, mediated by VAR2CSA, a variant of the PfEMP1 family of adhesion antigens. Recent studies have shown that many P. falciparum genomes have multiple genes coding for different VAR2CSA proteins, and parasites with >1 var2csa gene appear to be more common in...

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Identifiers

PMID: 21592998
DOI: 10.1093/infdis/jir168
PMCID: PMC3096795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.PMID 21592998Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected ErythrocytesSemantic proximity Read ↗

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” PhenotypeSemantic proximity Read ↗

Evidence for the Involvement of VAR2CSA in Pregnancy-associated MalariaSemantic proximity Read ↗

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.Semantic proximity Read ↗

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental MalariaSemantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant WomenSemantic proximity Read ↗

Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.Semantic proximity Read ↗

Multiple var2csa-Type PfEMP1 Genes Located at Different Chromosomal Loci Occur in Many Plasmodium falciparum IsolatesSemantic proximity Read ↗

Antibodies among Men and Children to Placental-Binding Plasmodium falciparum-Infected Erythrocytes that Express var2csaSemantic proximity Read ↗

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.Semantic proximity Read ↗

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