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Article

Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.

PloS one - 1 Jan 2014

Doritchamou Justin, Sossou-tchatcha Sylvain, Cottrell Gilles, Moussiliou Azizath, Hounton Houngbeme Christophe, Massougbodji Achille, Deloron Philippe, Ndam Nicaise Tuikue

Abstract excerpt

Pregnant women become susceptible to malaria infection despite their acquired immunity to this disease from childhood. The placental sequestration of Plasmodium falciparum infected erythrocytes (IE) is the major feature of malaria during pregnancy, due to ability of these parasites to bind chondroitin sulfate A (CSA) in the placenta through the VAR2CSA protein that parasites express on the surface of IE. We...

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Identifiers

PMID: 24905223
DOI: 10.1371/journal.pone.0098577
PMCID: PMC4048182

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.PMID 24905223Read ↗

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” PhenotypeSemantic proximity Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.Semantic proximity Read ↗

Variable Adhesion Abilities and Overlapping Antigenic Properties in PlacentalPlasmodium falciparumIsolatesSemantic proximity Read ↗

Evidence for the Involvement of VAR2CSA in Pregnancy-associated MalariaSemantic proximity Read ↗

Nonimmune immunoglobulin binding and multiple adhesion characterize <i>Plasmodium falciparum</i> -infected erythrocytes of placental originSemantic proximity Read ↗

Antibodies among Men and Children to Placental-Binding Plasmodium falciparum-Infected Erythrocytes that Express var2csaSemantic proximity Read ↗

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental MalariaSemantic proximity Read ↗

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected ErythrocytesSemantic proximity Read ↗

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.Semantic proximity Read ↗

Selective upregulation of a single distinctly structured <i>var</i> gene in chondroitin sulphate A‐adhering <i>Plasmodium falciparum</i> involved in pregnancy‐associated malariaSemantic proximity Read ↗

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.Semantic proximity Read ↗

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