Selective upregulation of a single distinctly structured <i>var</i> gene in chondroitin sulphate A‐adhering <i>Plasmodium falciparum</i> involved in pregnancy‐associated malaria

Abstract excerpt

Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite-encoded, clonally variant surface antigens (VSA) and is a central process in the pathogenesis of Plasmodium falciparum malaria. Pregnancy-associated malaria (PAM) has been linked to VSA-mediated adhesion of iRBC to the glycosaminoglycan chondroitin sulphate A (CSA) in the placental intervillous space. Several studies have pointed to...

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