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Article

Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria

1 Nov 2004

Abstract excerpt

In Plasmodium falciparum-endemic areas, pregnancy-associated malaria (PAM) is an important health problem. The condition is precipitated by accumulation of parasite-infected erythrocytes (IEs) in the placenta, and this process is mediated by parasite-encoded variant surface antigens (VSA) binding to chondroitin sulfate A (CSA). Parasites causing PAM express unique VSA types, VSAPAM, which can be serologically...

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Identifiers

PMID: 15520249
DOI: 10.1084/jem.20041579

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for the Involvement of VAR2CSA in Pregnancy-associated MalariaPMID 15520249Read ↗

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected ErythrocytesSemantic proximity Read ↗

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.Semantic proximity Read ↗

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” PhenotypeSemantic proximity Read ↗

Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant WomenSemantic proximity Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.Semantic proximity Read ↗

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental MalariaSemantic proximity Read ↗

VAR2CSA and protective immunity against pregnancy-associated<i>Plasmodium falciparum</i>malariaSemantic proximity Read ↗

Effects of Sex, Parity, and Sequence Variation on Seroreactivity to Candidate Pregnancy Malaria Vaccine AntigensSemantic proximity Read ↗

Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.Semantic proximity Read ↗

Antibodies among Men and Children to Placental-Binding Plasmodium falciparum-Infected Erythrocytes that Express var2csaSemantic proximity Read ↗

Plasmodium falciparum VAR2CSA-Specific IgG Subclass Responses Reflect Protection Against Low Birth Weight and Pregnancy-Associated MalariaSemantic proximity Read ↗

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