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Article

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.

PloS one - 19 Sept 2007

Viebig Nicola K, Levin Emily, Dechavanne Sébastien, Rogerson Stephen J, Gysin Jürg, Smith Joseph D, Scherf Artur, Gamain Benoit

Abstract excerpt

Infection with Plasmodium falciparum during pregnancy is one of the major causes of malaria related morbidity and mortality in newborn and mothers. The complications of pregnancy-associated malaria result mainly from massive adhesion of Plasmodium falciparum-infected erythrocytes (IE) to chondroitin sulfate A (CSA) present in the placental intervillous blood spaces. Var2CSA, a member of the P. falciparum...

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Identifiers

PMID: 17878945
DOI: 10.1371/journal.pone.0000910
PMCID: PMC1975670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.PMID 17878945Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected ErythrocytesSemantic proximity Read ↗

Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.Semantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental MalariaSemantic proximity Read ↗

Induction of Adhesion-Inhibitory Antibodies against Placental<i>Plasmodium falciparum</i>Parasites by Using Single Domains of VAR2CSASemantic proximity Read ↗

Cross-Reactive Surface Epitopes on Chondroitin Sulfate A-AdherentPlasmodium falciparum-Infected Erythrocytes Are Associated with Transcription ofvar2csaSemantic proximity Read ↗

Evidence for the Involvement of VAR2CSA in Pregnancy-associated MalariaSemantic proximity Read ↗

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” PhenotypeSemantic proximity Read ↗

Variable Adhesion Abilities and Overlapping Antigenic Properties in PlacentalPlasmodium falciparumIsolatesSemantic proximity Read ↗

Nonimmune immunoglobulin binding and multiple adhesion characterize <i>Plasmodium falciparum</i> -infected erythrocytes of placental originSemantic proximity Read ↗

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.Semantic proximity Read ↗

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