Article
Recovery of mature hepatocytic phenotype following bile ductular transdifferentiation of rat hepatocytes in vitro.
The American journal of pathology - 1 Dec 2012
Sone Masayuki, Nishikawa Yuji, Nagahama Yasuharu, Kumagai Eriko, Doi Yuko, Omori Yasufumi, Yoshioka Toshiaki, Tokairin Takuo, Yoshida Masayuki, Sugiyama Toshihiro, Enomoto Katsuhiko
Abstract excerpt
We previously demonstrated that mature rat hepatocytes transdifferentiate to bile ductular cells when cultured in a three-dimensional collagen-rich matrix. Here, we show that the phenotype of transdifferentiated hepatocytes can be reversed by modulating culture conditions. Spheroidal aggregates of hepatocytes were cultured within a collagen gel matrix in the presence of serum and tumor necrosis factor-α....
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