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Article

IL-8 induces transdifferentiation of mature hepatocytes toward the cholangiocyte phenotype.

FEBS open bio - 1 Dec 2019

Sasaki Tokio, Suzuki Yuji, Kakisaka Keisuke, Wang Ting, Ishida Kazuyuki, Suzuki Akiko, Abe Hiroaki, Sugai Tamotsu, Takikawa Yasuhiro

Abstract excerpt

The adult mammalian liver exhibits a remarkable regenerative capacity, with different modes of regeneration according to the type and extent of injury. Hepatocyte-cholangiocyte biphenotypic liver progenitor cell populations appear under conditions of excessive injury. It has been reported that mature hepatocytes can transdifferentiate toward a cholangiocyte phenotype and be a cellular source of progenitor cell...

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Identifiers

PMID: 31651102
DOI: 10.1002/2211-5463.12750
PMCID: PMC6886300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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