Article
Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures.
Current drug metabolism - 1 Aug 2006
Elaut Greetje, Henkens Tom, Papeleu Peggy, Snykers Sarah, Vinken Mathieu, Vanhaecke Tamara, Rogiers Vera
Abstract excerpt
Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic biotransformation, enzyme induction and inhibition, and (biotransformation-mediated) hepatotoxicity. In addition, hepatocyte cultures have proven to be valuable tools in the study of liver physiology, viral hepatitis, and liver...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.