Article
Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994
Wu J C, Merlino G, Fausto N
Abstract excerpt
Hepatocytes are extensively used in studies of gene regulation but cannot be maintained in long-term culture as replicating, differentiated cells while remaining nontumorigenic. We have derived two hepatocyte lines from livers of transgenic mice overexpressing transforming growth factor alpha, a...
Topics
- Animals
- Blood Proteins
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Connexins
- ErbB Receptors
- Isoenzymes
- L-Lactate Dehydrogenase
- Liver
- Male
- Mice
- Mice, Nude
- Mice, Transgenic
- Phenotype
- Proteins
- RNA, Messenger