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Article

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Wu J C, Merlino G, Fausto N

Abstract excerpt

Hepatocytes are extensively used in studies of gene regulation but cannot be maintained in long-term culture as replicating, differentiated cells while remaining nontumorigenic. We have derived two hepatocyte lines from livers of transgenic mice overexpressing transforming growth factor alpha, a potent hepatocyte mitogen, which overcome these limitations. The transgenic hepatocytes were maintained for > or = 2...

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Identifiers

PMID: 7904757
DOI: 10.1073/pnas.91.2.674
PMCID: PMC43011

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