Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Abstract excerpt

Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentiation and the differentiation potential of dedifferentiated hepatocytes (dediHeps) require further investigation. Here, we employ a culture system specifically established for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to FOXO transcription factor regulation
• Share to Liver physiology and pathology
• Share to Pancreatic function and diabetes