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Article

Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior.

The European journal of neuroscience - 1 Jan 2013

Spencer Sade, Falcon Edgardo, Kumar Jaswinder, Krishnan Vaishnav, Mukherjee Shibani, Birnbaum Shari G, McClung Colleen A

Abstract excerpt

It has been suggested for some time that circadian rhythm abnormalities underlie the development of multiple psychiatric disorders. However, it is unclear how disruptions in individual circadian genes might regulate mood and anxiety. Here we found that mice lacking functional mPeriod 1 (mPer1) or mPeriod 2 (mPer2) individually did not have consistent behavioral abnormalities in measures of anxiety-related...

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Source

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Identifiers

PMID: 23039899
DOI: 10.1111/ejn.12010
PMCID: PMC3711746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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