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Article

The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels.

Behavioural brain research - 15 Jul 2013

Gamsby J J, Templeton E L, Bonvini L A, Wang W, Loros J J, Dunlap J C, Green A I, Gulick D

Abstract excerpt

BACKGROUND: Perturbations in the function of core circadian clock components such as the Period (Per) family of genes are associated with alcohol use disorder, and disruptions in circadian cycles may contribute to alcohol abuse and relapse. This study tested ethanol consumption, reinforcement, and metabolism in mice containing functional mutations in Per1 and/or Per2 genes on an ethanol-preferring background,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23608482
DOI: 10.1016/j.bbr.2013.04.016
PMCID: PMC3672323

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