Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.

doi:10.1016/j.neurobiolaging.2012.08.010

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Article

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.

Neurobiology of aging - 1 Apr 2013

Bullock James M, Medway Christopher, Cortina-Borja Mario, Turton James C, Prince Jonathan A, Ibrahim-Verbaas Carla A, Schuur Maaike, Breteler Monique M, van Duijn Cornelia M, Kehoe Patrick G, Barber Rachel, Coto Eliecer, Alvarez Victoria, Deloukas Panos, Hammond Naomi, Combarros Onofre, Mateo Ignacio, Warden Donald R, Lehmann Michael G, Belbin Olivia, Brown Kristelle, Wilcock Gordon K, Heun Reinhard, Kölsch Heike, Smith A David, Lehmann Donald J, Morgan Kevin

Abstract excerpt

Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial "hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, interactions. We examined potential epistasis between 110 candidate polymorphisms in 1757 cases of Alzheimer's disease and 6294 control subjects of the Epistasis Project, divided between a...

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Identifiers

PMID: 23036584
DOI: 10.1016/j.neurobiolaging.2012.08.010

Genes

GSTM3
HHEX
IDE
KIF11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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