Article
Investigating statistical epistasis in complex disorders.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Turton James C, Bullock James, Medway Christopher, Shi Hui, Brown Kristelle, Belbin Olivia, Kalsheker Noor, Carrasquillo Minerva M, Dickson Dennis W, Graff-Radford Neill R, Petersen Ronald C, Younkin Steven G, Morgan Kevin
Abstract excerpt
The missing heritability exhibited by late-onset Alzheimer's disease is unexplained and has been partly attributed to epistatic interaction. Methods available to explore this are often based on logistic regression and allow for determination of deviation from an expected outcome as a result of st...
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