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Article

Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species-specific regulation of blood pressure.

Physiological reports - 1 Feb 2020

Mercado Carlo J, Wang Xiaochun, Grimm Paul R, Welling Paul A, Chang Yen-Pei C

Abstract excerpt

STK39 encodes a serine threonine kinase, SPAK, which is part of a multi-kinase network that determines renal Na+ reabsorption and blood pressure (BP) through regulation of sodium-chloride co-transporters in the kidney. Variants within STK39 are associated with susceptibility to essential hypertension, and constitutively active SPAK mice are hypertensive and hyperkalemic, similar to familial hyperkalemic...

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Identifiers

PMID: 32109341
DOI: 10.14814/phy2.14379
PMCID: PMC7048380

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