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Article

Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2013

Schacht Joseph P, Anton Raymond F, Voronin Konstantin E, Randall Patrick K, Li Xingbao, Henderson Scott, Myrick Hugh

Abstract excerpt

Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPRM1), A118G (Asn40Asp), may moderate naltrexone (NTX) effects in alcohol dependence. Both NTX and A118G variation have also been reported to affect alcohol cue-elicited brain activation. This study investigated whether sub-acute NTX treatment and A118G genotype interacted in their effects on cue-elicited activation of the ventral...

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Source

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Identifiers

PMID: 23032071
DOI: 10.1038/npp.2012.195
PMCID: PMC3547192

Genes

OPRM1

Variants

Provenance

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Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues.PMID 23032071Read ↗

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Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial.Semantic proximity Read ↗

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