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Article

APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.

PloS one - 1 Jan 2012

Li Ruwei, Wan Bo, Zhou Jun, Wang Yingli, Luo Ting, Gu Xiuting, Chen Fang, Yu Long

Abstract excerpt

Studies of brain-specific kinase 2 (BRSK2), an AMP-activated protein kinase (AMPK)-related kinase, and its homologs suggest that they are multifunctional regulators of cell-cycle progression. BRSK2, which contains a ubiquitin-associated (UBA) domain, is polyubiquitinated in cells. However, the regulatory mechanisms and exact biological function of BRSK2 remain unclear. Herein, we show that BRSK2 co-localizes with...

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Source

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Identifiers

PMID: 23029325
DOI: 10.1371/journal.pone.0045932
PMCID: PMC3448725

Genes

BRSK2
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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