Article
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.
Molecular biology of the cell - 1 Jul 2009
Gao Daming, Inuzuka Hiroyuki, Korenjak Michael, Tseng Alan, Wu Tao, Wan Lixin, Kirschner Marc, Dyson Nicholas, Wei Wenyi
Abstract excerpt
APC/Cdh1 is a major cell cycle regulator and its function has been implicated in DNA damage repair; however, its exact role remains unclear. Using affinity purification coupled with mass spectrometry, we identified Claspin as a novel Cdh1-interacting protein and further demonstrated that Claspin is a novel Cdh1 ubiquitin substrate. As a result, inactivation of Cdh1 leads to activation of the Claspin/Chk1 pathway....
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