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Article

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Molecular cell - 1 Oct 2015

Lee Seung Baek, Kim Jung Jin, Nam Hyun-Ja, Gao Bowen, Yin Ping, Qin Bo, Yi Sang-Yeop, Ham Hyoungjun, Evans Debra, Kim Sun-Hyun, Zhang Jun, Deng Min, Liu Tongzheng, Zhang Haoxing, Billadeau Daniel D, Wang Liewei, Giaime Emilie, Shen Jie, Pang Yuan-Ping, Jen Jin, van Deursen Jan M, Lou Zhenkun

Abstract excerpt

Mutations in the E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Parkin has also been implicated in mitosis through mechanisms that are unclear. Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) coactivators Cdc20 and Cdh1 to mediate the degradation of several key mitotic regulators independent of APC/C. We demonstrate that ordered progression...

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Identifiers

PMID: 26387737
DOI: 10.1016/j.molcel.2015.08.011
PMCID: PMC4592523

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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