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Article

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.

The EMBO journal - 20 Feb 2008

Rodier Geneviève, Coulombe Philippe, Tanguay Pierre-Luc, Boutonnet Christel, Meloche Sylvain

Abstract excerpt

The p27(Kip1) ubiquitin ligase receptor Skp2 is often overexpressed in human tumours and displays oncogenic properties. The activity of SCF(Skp2) is regulated by the APC(Cdh1), which targets Skp2 for degradation. Here we show that Skp2 phosphorylation on Ser64/Ser72 positively regulates its funct...

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Share to Anaphase-Promoting Complex-Cyclosome
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Source

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Identifiers

PMID: 18239684
DOI: 10.1038/emboj.2008.6
PMCID: PMC2262036

Genes

APC
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18239684-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.PMID 18239684Read ↗

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