Article
Loss of CCR7 expression on CD56(bright) NK cells is associated with a CD56(dim)CD16⁺ NK cell-like phenotype and correlates with HIV viral load.
PloS one - 1 Jan 2012
Hong Henoch S, Ahmad Fareed, Eberhard Johanna M, Bhatnagar Nupur, Bollmann Benjamin A, Keudel Phillip, Ballmaier Matthias, Zielinska-Skowronek Margot, Schmidt Reinhold E, Meyer-Olson Dirk
Abstract excerpt
NK cells are pivotal sentinels of the innate immune system and distinct subpopulations in peripheral blood have been described. A number of studies addressed HIV-induced alterations of NK cell phenotype and functionality mainly focusing on CD56(dim)CD16⁺ and CD56⁻CD16⁺ NK cells. However, the impact of HIV-infection on CD56(bright) NK cells is less well understood. Here we report a rise of CD56(bright) NK cells in...
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