Article
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008
Dulphy Nicolas, Haas Philippe, Busson Marc, Belhadj Stéphanie, Peffault de Latour Régis, Robin Marie, Carmagnat Maryvonnick, Loiseau Pascale, Tamouza Ryad, Scieux Catherine, Rabian Claire, Di Santo James P, Charron Dominique, Janin Anne, Socié Gérard, Toubert Antoine
Abstract excerpt
The expansion of the cytokine-producing CD56(bright) NK cell subset is a main feature of lymphocyte reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT). We investigated phenotypes and functions of CD56(bright) and CD56(dim) NK subsets from 43 HLA-matched non-T cell-depleted HSCT donor-recipient pairs. The early expansion of CD56(bright) NK cells gradually declined in the posttransplant...
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