Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.

PLoS genetics - 1 Sept 2012

Korostowski Lisa, Sedlak Natalie, Engel Nora

Abstract excerpt

Although many of the questions raised by the discovery of imprinting have been answered, we have not yet accounted for tissue- or stage-specific imprinting. The Kcnq1 imprinted domain exhibits complex tissue-specific expression patterns co-existing with a domain-wide cis-acting control element. Transcription of the paternally expressed antisense non-coding RNA Kcnq1ot1 silences some neighboring genes in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Imprinting

Share to KCNQ1 Potassium Channel

Share to Myocytes, Cardiac

Share to Organ Specificity

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 23028363
DOI: 10.1371/journal.pgen.1002956
PMCID: PMC3447949

Genes

CAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.PMID 23028363Read ↗

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.Semantic proximity Read ↗

Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1.Semantic proximity Read ↗

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.Semantic proximity Read ↗

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencerSemantic proximity Read ↗

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region.Semantic proximity Read ↗

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.Semantic proximity Read ↗

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.Semantic proximity Read ↗

Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region.Semantic proximity Read ↗

Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.Semantic proximity Read ↗

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.Semantic proximity Read ↗

Cardiac muscle-restricted partial loss of <i>Nos1ap</i> expression has limited impact on electro- and echo-cardiographic featuresSemantic proximity Read ↗

Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.