Article
Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1.
Genomics - 1 Nov 1998
Jiang S, Hemann M A, Lee M P, Feinberg A P
Abstract excerpt
Genomic imprinting is an epigenetic modification of the gamete or zygote leading to parental origin-specific differential expression of the two alleles of a gene in somatic cells of the offspring. We previously reported that the human KVLQT1 gene is imprinted and disrupted in patients with germli...
Topics
- Alleles
- Animals
- Base Sequence
- Crosses, Genetic
- DNA Primers
- Female
- Genomic Imprinting
- Humans
- KCNQ Potassium Channels
- KCNQ1 Potassium Channel
- Male
- Mice
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Potassium Channels
- Potassium Channels, Voltage-Gated
- Pregnancy
- RNA