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Article

Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1.

Genomics - 1 Nov 1998

Jiang S, Hemann M A, Lee M P, Feinberg A P

Abstract excerpt

Genomic imprinting is an epigenetic modification of the gamete or zygote leading to parental origin-specific differential expression of the two alleles of a gene in somatic cells of the offspring. We previously reported that the human KVLQT1 gene is imprinted and disrupted in patients with germline balanced chromosomal rearrangements and Beckwith-Wiedemann syndrome. In human, the gene is imprinted in most fetal...

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PMID: 9799609
DOI: 10.1006/geno.1998.5511

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1.PMID 9799609Read ↗

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.Semantic proximity Read ↗

Imprinting of mouse Kvlqt1 is developmentally regulated.Semantic proximity Read ↗

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.Semantic proximity Read ↗

Sequence-based bioinformatic prediction and QUASEP identify genomic imprinting of the KCNK9 potassium channel gene in mouse and human.Semantic proximity Read ↗

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndromeSemantic proximity Read ↗

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.Semantic proximity Read ↗

Haldane’s rule in the placenta: sex-biased misregulation of the <i>Kcnq1</i> imprinting cluster in hybrid miceSemantic proximity Read ↗

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangementsSemantic proximity Read ↗

Intraspecific mating with CzechII/Ei mice rescue lethality associated with loss of function mutations of the imprinted genes, Igf2r and Cdkn1c.Semantic proximity Read ↗

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.Semantic proximity Read ↗

Global survey of genomic imprinting by transcriptome sequencing.Semantic proximity Read ↗

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