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Article

Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.

Development (Cambridge, England) - 1 Aug 2010

Mohammad Faizaan, Mondal Tanmoy, Guseva Natalia, Pandey Gaurav Kumar, Kanduri Chandrasekhar

Abstract excerpt

A long noncoding RNA, Kcnq1ot1, regulates the expression of both ubiquitously and tissue-specific imprinted genes within the Kcnq1 domain. However, the functional sequences of the Kcnq1ot1 RNA that mediate lineage-specific imprinting are unknown. Here, we have generated a knockout mouse with a deletion encompassing an 890-bp silencing domain (Delta890) downstream of the Kcnq1ot1 promoter. Maternal transmission of...

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Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Developmental

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Share to RNA, Long Noncoding

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Source

Identifiers

PMID: 20573698
DOI: 10.1242/dev.048181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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