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Article

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.

Development (Cambridge, England) - 1 Nov 2006

Lewis Annabelle, Green Kelly, Dawson Claire, Redrup Lisa, Huynh Khanh D, Lee Jeannie T, Hemberger Myriam, Reik Wolf

Abstract excerpt

The mouse Kcnq1 imprinted domain is located on distal chromosome 7 and contains several imprinted genes that are paternally repressed. Repression of these genes is regulated by a non-coding antisense transcript, Kcnq1ot1, which is paternally expressed. Maternal repression of Kcnq1ot1 is controlle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotides, Antisense

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Source

Identifiers

PMID: 17021040
DOI: 10.1242/dev.02612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17021040-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.PMID 17021040Read ↗

Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.Semantic proximity Read ↗

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencerSemantic proximity Read ↗

G9a Histone Methyltransferase Contributes to Imprinting in the Mouse PlacentaSemantic proximity Read ↗

Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region.Semantic proximity Read ↗

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexesSemantic proximity Read ↗

Differentiation-driven nucleolar association of the mouse imprinted Kcnq1 locus.Semantic proximity Read ↗

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.Semantic proximity Read ↗

Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.Semantic proximity Read ↗

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.Semantic proximity Read ↗

Maternal H3K27me3 controls DNA methylation-independent imprinting.Semantic proximity Read ↗

Limited evolutionary conservation of imprinting in the human placenta.Semantic proximity Read ↗

Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.Semantic proximity Read ↗

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