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Article

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region.

Molecular and cellular biology - 1 Sept 2004

Thakur Noopur, Tiwari Vijay Kumar, Thomassin Helene, Pandey Radha Raman, Kanduri Meena, Göndör Anita, Grange Thierry, Ohlsson Rolf, Kanduri Chandrasekhar

Abstract excerpt

The Kcnq1 imprinting control region (ICR) located in intron 10 of the Kcnq1 gene is unmethylated on the paternal chromosome and methylated on the maternal chromosome and has been implicated in the manifestation of parent-of-origin-specific expression of six neighboring genes. The unmethylated Kcnq1 ICR harbors bidirectional silencer activity and drives expression of an antisense RNA, Kcnq1ot1, which overlaps the...

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Identifiers

PMID: 15340049
DOI: 10.1128/MCB.24.18.7855-7862.2004
PMCID: PMC515059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region.PMID 15340049Read ↗

Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region.Semantic proximity Read ↗

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.Semantic proximity Read ↗

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.Semantic proximity Read ↗

A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.Semantic proximity Read ↗

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencerSemantic proximity Read ↗

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.Semantic proximity Read ↗

Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndromeSemantic proximity Read ↗

Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.Semantic proximity Read ↗

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.Semantic proximity Read ↗

The KCNQ1OT1 promoter, a key regulator of genomic imprinting in human chromosome 11p15.5.Semantic proximity Read ↗

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.Semantic proximity Read ↗

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.Semantic proximity Read ↗

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